![]() Results: After a median follow-up of 26.6 months, patients with a GPS of 0, 1, and 2 had PFS of 15.7, 10.0, and 6.3 months, respectively, and OS of 40.1, 25.8, and 14.4 months, respectively patients with a GPS of 0 had significantly better PFS and OS than those with a GPS of 1 ( p = 0.03, p = 0.001, respectively) or 2 ( p < 0.001, p < 0.001, respectively). The Kaplan-Meier method and Cox proportional hazards models were used to assess progression-free survival (PFS) and overall survival (OS). Methods: We evaluated 340 patients with NSCLC harboring sensitive EGFR mutations who received EGFR-TKI monotherapy between March 2009 and July 2021. Information regarding the association between the GPS and EGFR-TKI treatment effectiveness is limited hence, we investigated whether the GPS can predict the response of NSCLC to EGFR-TKIs. ![]() ![]() The Glasgow prognostic score (GPS) is an inflammation-assessing score based on C-reactive protein and albumin concentrations. Introduction: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with sensitive EGFR mutations.
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